Endocrine Abstracts

Autoimmune thyroid diseases (AITD), such as Hashimoto’s thyroiditis (HT) and Grave’s disease (GD) frequently form overlap syndromes with rheumatoid arthritis (RA). Among genetic factors, the role of the HLA antigens and CTLA4 gene polymorphisms in the formation of such overlap syndromes has been suggested.Objective: Aim of this study was to investigate the alleli and genotypes frequency of the CTLA4 exon1 A49G polymorphism in Slovak patients wi...

The aim of the present study was to evaluate and compare the response of 17 OHP to ACTH stimulation in patients with various types of adrenal incidentalomas and to examine the occurence of germline CYP21 mutation in these patients.Subjects and methods: Forty patients (27 females, 13 males) with unilateral and bilateral masses were screened for five most common mutations of the CYP21 in peripheral blood DNA samples. A hormonal evaluation, i.e. baseline pl...

Objectives: Aim of the study was firstly to assess the prevalence of metabolic symptoms in patients with clinically silent and benign adrenal incidentalomas (AI) and secondly to determine the prevalence of C825T GNB3 gene polymorphism in AI as well as its relation to metabolic variables.Subject and methods: Group of patients consisted of 50 patients with AI of mean age 57.9±15 years and group of controls consisted of 22 subjects without AI and metab...